Viagra (Sildenafil)

Abrams and cl 34 reported the use of sildenafil at a dose of 2 mg/kg every 6 hours in achild 4 years of age with primary pulmonary hypertension after poor responseto intravenous prostacyclin. The improvement in clinical status occur contiue withadministration of sildenafil every 4 hours, allowing the suspension of prostacyclin andof oxygen. At 3 months the child had continued in the tolerance to emlhoraexercises and without adverse effects. In 2002, Atz and cl 35 published another study describing the use of sildenafil incombination with nitric oxide in a child a 9 months of age with repeated attackspulmonary hypertension after mitral valve placement. Sildenafil was administered indose of 0. 3 mg / kg Through a nasogastric tube every 4 hours. The administration of theallowed a gradual weaning sildenafil and nitric oxide was discontinued on day 15. The mean pulmonary artery pressure remained approximately 60 to 70% of the pressuresystemic blood during treatment. Sildenafil was suspended on the 22 nd postoperative day without the occurrence of rebound pulmonary hypertension and without adverse effects. 33 Carroll and Dhillon used sildenafil at a dose of 0. 51 mg / kg every 6 hours, coming to an end with 2 mg/kg every 6 hours in three pediatrics patients. Two of thesepatients had primary pulmonary hypertension and a laugh, had surgical correction oftransposition of great arteries after 22 days to develop pulmonary hypertension 7 years. Two of the patients showed initial positive response, while a patient is notwas change in pulmonary artery pressure. None of the children had effectsadverse. As in previous cases, the authors suggested that sildenafil should beconsidered an option for children with pulmonary hypertension that requires a longtherapy. 36 Hon and cl in 2004, used sildenafil at a dose of 0. 9 mg / kg / ddia 8 / 8 hourswith gradual increase to 1. 8 mg / kg / day 4 / 4 hours in a child of 5 monthsbronchopulmonary dysplasia and severe pulmonary hypertension refractory to vasodilator therapyconventional and maximum parameters of the respirator. The drug was used for 6 months untilcomplete resolution of pulmonary hypertension. 37 Bentlin cl and used sildenafil at a dose of 0. 5 mg / kg / dose 6 / 6 hours orallyin a newborn with pulmonary hypertension after cardiac surgery that has not responded to the useendovebosos prostaglandin E 1. With 48 hours was possible to discontinue prostaglandin E 1.